dc.creator | Solis, | |
dc.creator | Gonzalez, R. | |
dc.creator | Castillo, | |
dc.creator | Lillo, | |
dc.creator | Alliende, | |
dc.date.accessioned | 2018-12-20T15:09:11Z | |
dc.date.available | 2018-12-20T15:09:11Z | |
dc.date.created | 2018-12-20T15:09:11Z | |
dc.date.issued | 1993 | |
dc.identifier | American Journal of Physiology - Gastrointestinal and Liver Physiology, Volumen 265, Issue 3 28-3, 2018, | |
dc.identifier | 00029513 | |
dc.identifier | http://repositorio.uchile.cl/handle/2250/157964 | |
dc.description.abstract | The chronic daily administration of isoproterenol provokes in mouse parotid glands the induction and progressive accumulation of a family of secretory polypeptides named polypeptides C, D, E, F, and G (polypeptides C- G). These polypeptides, which seem to be part of the family of proline-rich proteins, have been considered as molecular markers of the growth-in-size response in the mouse parotid acinar cells. In the present study, two pharmacological approaches were used to determine whether the induction and the postsecretory reappearance of polypeptides C-G may be distinguished from each other. First, actinomycin D, a transcriptional inhibitor, was found to interfere with the induction by isoproterenol but not with the postsecretory reappearance. Second, pilocarpine, a secretagogue that was found to be a very weak inducer of polypeptides C-G, was able to provoke secretion and then reappearance of the whole group of isoproterenol-induced polypeptides. Accordingly, these data suggest th | |
dc.language | en | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | American Journal of Physiology - Gastrointestinal and Liver Physiology | |
dc.subject | hypertrophy | |
dc.subject | proline-rich proteins | |
dc.subject | protein synthesis | |
dc.title | Transcriptional and posttranscriptional control in synthesis of growth marker polypeptides in mouse parotids | |
dc.type | Artículos de revistas | |