A polarographic study of the photodegradation of nitrendipine

dc.creatorSquella Serrano, Juan
dc.creatorZanocco, A.
dc.creatorPerna, S.
dc.creatorNúñez Vergara, Luis
dc.date.accessioned2018-12-20T15:05:12Z
dc.date.available2018-12-20T15:05:12Z
dc.date.created2018-12-20T15:05:12Z
dc.date.issued1990
dc.identifierJournal of Pharmaceutical and Biomedical Analysis, Volumen 8, Issue 1, 2018, Pages 43-47
dc.identifier07317085
dc.identifier10.1016/0731-7085(90)80005-A
dc.identifierhttps://repositorio.uchile.cl/handle/2250/157721
dc.description.abstractNitrendipine produces a well-defined polarographic peak due to the four-electron reduction of the nitro group. This peak is used for tracking the photodecomposition of nitrendipine in both UV light and daylight conditions. The results show that nitrendipine remains unaltered in the short time scale of a normal analytical procedure and no special care with visible light exposure is necessary. However nitrendipine is strongly altered with UV irradiation showing a first-order degradation kinetics. A degradation rate constant of 0.0665 min-1 with a t 1 2, of 10.423 min has been obtained. The UV degradation product was isolated and identified as the nitro pyridine analogue of nitrendipine. © 1990.
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceJournal of Pharmaceutical and Biomedical Analysis
dc.subjectDifferential pulse polarography
dc.subjectnitrendipine photodegradation.
dc.titleA polarographic study of the photodegradation of nitrendipine
dc.typeArtículo de revista


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