Experimental cardio-depressant effects of clonixin

dc.creatorBustamante, D.
dc.creatorMorales, M.
dc.creatorPelissier Serrano, Teresa
dc.creatorSaavedra, H.
dc.creatorMiranda, H.
dc.creatorPaeile, C.
dc.date.accessioned2018-12-20T15:05:11Z
dc.date.available2018-12-20T15:05:11Z
dc.date.created2018-12-20T15:05:11Z
dc.date.issued1989
dc.identifierGeneral Pharmacology, Volumen 20, Issue 5, 1989, Pages 605-608
dc.identifier03063623
dc.identifier10.1016/0306-3623(89)90094-3
dc.identifierhttp://repositorio.uchile.cl/handle/2250/157705
dc.description.abstract1. The cardiovascular effects of CLX were studied. 2. CLX induced hypotension, bradycardia, negative chronotropism and negative inotropism. 3. Electrophysiological studies showed a decrease of sinus venosus discharge frequency. The action potential configuration was changed: the overshoot amplitude and (dV/dt)max were reduced and duration increased. 4. CLX at higher concentrations displaced the maximum diastolic potential and phase 4 slow diastolic depolarization was lengthened. 5. The above findings could be explained by a depressant action of CLX on the electrical activity of the pacemaker cells, possibly by a modification of the slow calcium currents.
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceGeneral Pharmacology
dc.subjectPharmacology
dc.titleExperimental cardio-depressant effects of clonixin
dc.typeArtículos de revistas


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