dc.creatorGonzález-Itier, Sergio
dc.creatorContreras, Esteban G.
dc.creatorLarraín, Juan
dc.creatorGlavic Maurer, Álvaro
dc.creatorFaunes, Fernando
dc.date.accessioned2018-12-20T14:22:47Z
dc.date.available2018-12-20T14:22:47Z
dc.date.created2018-12-20T14:22:47Z
dc.date.issued2018
dc.identifierMechanisms of Development, Volumen 154,
dc.identifier18726356
dc.identifier09254773
dc.identifier10.1016/j.mod.2018.06.002
dc.identifierhttps://repositorio.uchile.cl/handle/2250/155751
dc.description.abstract© 2018 Elsevier B.V.Insect metamorphosis has been a classic model to understand the role of hormones in growth and timing of developmental transitions. In addition to hormones, transitions in some species are regulated by genetic programs, such as the heterochronic gene network discovered in C. elegans. However, the functional link between hormones and heterochronic genes is not clear. The heterochronic gene lin-28 is involved in the maintenance of stem cells, growth and developmental timing in vertebrates. In this work, we used gain-of-function and loss-of-function experiments to study the role of Lin-28 in larval growth and the timing of metamorphosis of Drosophila melanogaster. During the late third instar stage, Lin-28 is mainly expressed in neurons of the central nervous system and in the intestine. Loss-of-function lin-28 mutant larvae are smaller and the larval-to-pupal transition is accelerated. This faster transition correlates with increased levels of ecdysone direct target g
dc.languageen
dc.publisherElsevier Ireland Ltd
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceMechanisms of Development
dc.subjectDevelopmental transitions
dc.subjectEcdysone signaling
dc.subjectGrowth
dc.subjectLin-28
dc.subjectMetamorphosis
dc.subjectPupariation
dc.titleA role for Lin-28 in growth and metamorphosis in Drosophila melanogaster
dc.typeArtículos de revistas


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