| dc.creator | García Beltrán, Olimpo | |
| dc.creator | Mena, Natalia | |
| dc.creator | Yañez, Osvaldo | |
| dc.creator | Caballero, Julio | |
| dc.creator | Vargas, Víctor | |
| dc.creator | Núñez González, Marco | |
| dc.creator | Cassels Niven, Bruce | |
| dc.date.accessioned | 2018-12-20T14:13:57Z | |
| dc.date.available | 2018-12-20T14:13:57Z | |
| dc.date.created | 2018-12-20T14:13:57Z | |
| dc.date.issued | 2013 | |
| dc.identifier | European Journal of Medicinal Chemistry, Volumen 67, | |
| dc.identifier | 17683254 | |
| dc.identifier | 02235234 | |
| dc.identifier | 10.1016/j.ejmech.2013.06.022 | |
| dc.identifier | https://repositorio.uchile.cl/handle/2250/155040 | |
| dc.description.abstract | A new coumarin-based 'turn-off' fluorescent probe, 7-(diethylamino)-N-(1,3- dihydroxy-2-(hydroxymethyl) propan-2-yl)-2-oxo-2H-chromene-3-carboxamide (AGD) was synthesized. This compound is highly selective for ferrous ions (Fe 2+) and can reversibly detect them in aqueous medium. The probe localizes to the cell membrane in living cells, where it can detect changes in Fe2+ concentration. Molecular dynamics (MD) simulations indicate that AGD interacts with the lipid bilayer at the level of the glycerol moieties. © 2013 Elsevier Masson SAS. All rights reserved. | |
| dc.language | en | |
| dc.publisher | Elsevier Masson SAS | |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.source | European Journal of Medicinal Chemistry | |
| dc.subject | Fluorescent sensor | |
| dc.subject | Molecular dynamics | |
| dc.subject | Turn-off probes | |
| dc.title | Design, synthesis and cellular dynamics studies in membranes of a new coumarin-based "turn-off" fluorescent probe selective for Fe 2+ | |
| dc.type | Artículo de revista | |
