dc.creator | Bravo, Javier A. | |
dc.creator | Parra, Claudio S. | |
dc.creator | Arancibia, Sandor | |
dc.creator | Andrés, Sergio | |
dc.creator | Morales Retamales, Paola | |
dc.creator | Herrera-Marschitz Muller, Mario | |
dc.creator | Herrera, Luisa | |
dc.creator | Lara Peñaloza, Hernán | |
dc.creator | Fiedler Temer, Jenny | |
dc.date.accessioned | 2018-12-20T14:11:17Z | |
dc.date.available | 2018-12-20T14:11:17Z | |
dc.date.created | 2018-12-20T14:11:17Z | |
dc.date.issued | 2006 | |
dc.identifier | BMC Neuroscience, Volumen 7, | |
dc.identifier | 14712202 | |
dc.identifier | 14712202 | |
dc.identifier | 10.1186/1471-2202-7-40 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/154540 | |
dc.description.abstract | Background: Corticosterone reduction produced by adrenalectomy (ADX) induces apoptosis in dentate gyrus (DG) of the hippocampus, an effect related to an increase in the expression of the pro-apoptotic gene bax. However it has been reported that there is also an increase of the anti-apoptotic gene bcl-2, suggesting the promotion of a neuroprotective phenomenon, perhaps related to the expression of transforming growth factor β1 (TGF-β1). Thus, we have investigated whether TGF-β1 levels are induced by ADX, and whether apoptosis is increased by blocking the expression of TGF-β1 with an antisense oligonucleotide (ASO) administered intracerebrally in corticosterone depleted rats. Results: It was observed an increase of apoptosis in DG, 2 and 5 days after ADX, in agreement with a reduction of corticosterone levels. However, the effect of ADX on the number of apoptotic positive cells in DG was decreased 5 days after the lesion. In CA1-CA3 regions, the effect was only observed 2 days after ADX. | |
dc.language | en | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | BMC Neuroscience | |
dc.subject | Neuroscience (all) | |
dc.subject | Cellular and Molecular Neuroscience | |
dc.title | Adrenalectomy promotes a permanent decrease of plasma corticoid levels and a transient increase of apoptosis and the expression of Transforming Growth Factor β1 (TGF-β1) in hippocampus: Effect of a TGF-β1 oligo-antisense | |
dc.type | Artículos de revistas | |