dc.creator | Rosenblut, Andrés | |
dc.creator | Rosenblut, Macarena | |
dc.creator | García, Karen | |
dc.creator | Maul, Ximena | |
dc.creator | Santolaya de Pablo, María Elena | |
dc.date.accessioned | 2018-08-07T21:14:15Z | |
dc.date.available | 2018-08-07T21:14:15Z | |
dc.date.created | 2018-08-07T21:14:15Z | |
dc.date.issued | 2018 | |
dc.identifier | Pediatric infectious Disease Journal Volumen: 37 Número: 2 Páginas: 132-134 | |
dc.identifier | 10.1097/INF.0000000000001722 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/150750 | |
dc.description.abstract | Background:Streptococcus pneumoniae is the leading cause of acute otitis media (AOM). Ten-valent pneumococcal conjugated vaccine (PCV-10) was introduced to the Chilean National Immunization Program (NIP) in 2011. The aim of this study was to estimate the frequency of AOM in children <24 months of age attending the emergency department (ED) of Hospital Sotero del Rio (HSR) 4 years before and 4 years after the introduction of PCV-10 in the Chilean NIP.
Methods: Register-based nested case-control study. Cases (n = 1907) were all children <24 months of age with a clinical diagnosis discharge of AOM at the ED of HSR, and controls (n = 244,334) were all other children <24 months of age attended at the same ED in the same time period, with any other discharge diagnosis. The data were obtained through HSR Statistical Service.
Results: In the study period, there was a mean of 30,695 children <24 months managed each year at the ED of HSR. The percentage with AOM in the prevaccine period was 0.94% and in the postvaccine period was 0.62%, respectively (P = 0.026). Exposure to the PCV-10 was associated with a decreased risk to develop AOM in children <24 months, with an odds ratio of 0.659 (95% confidence interval: 0.60-0.72).
Conclusions: Our study showed a significant decrease in the percentage and risk of AOM in children <24 months of age who visited the ED of HSR after implementation of PCV-10 in the NIP in Chile. | |
dc.language | en | |
dc.publisher | Lippincontt Williams & Wilkins | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Pediatric infectious Disease Journal | |
dc.subject | Acute otitis media | |
dc.subject | Pneumococcal vaccine | |
dc.subject | Pediatrics | |
dc.title | Frequency of acute otitis media in children under 24 months of age before and after the introduction of the 10-valent pneumococcal Conjugate Vaccine Into the national immunization program in Chile | |
dc.type | Artículo de revista | |