dc.creatorAlmada, M.
dc.creatorLeal Martínez, B. H.
dc.creatorHassan, N.
dc.creatorKogan Bocian, Marcelo
dc.creatorBurboa, M. G.
dc.creatorTopete, A.
dc.creatorValdez, M. A.
dc.creatorJuarez, J.
dc.date.accessioned2018-05-16T20:56:07Z
dc.date.available2018-05-16T20:56:07Z
dc.date.created2018-05-16T20:56:07Z
dc.date.issued2017
dc.identifierMaterials Science and Engineering C 77 (2017) 583–593
dc.identifier10.1016/j.msec.2017.03.218
dc.identifierhttp://repositorio.uchile.cl/handle/2250/147818
dc.description.abstractGold nanorods (GNR) use has been proposed in medical applications because of their intrinsic photothermal properties. However, the presence of CTAB molecules adsorbed onto the surface of GNRs results in a highly cytotoxic GNR system. In this work we replace the CTAB molecules with a thiolated chitosan. Once chitosan coated GNRs (Chi-5H-GNR) were attained, a film of alginate (Alg-Chi-SH-GNR) or polyvinyl alcohol (PVA-ChiSH-GNR) was deposited onto the surface of Chi-GNR by a layer -by -layer process. The photothermal conversion efficiency for the GNR systems was determined irradiating the GNRs suspended in aqua media with a CW 808 nm diode laser (CNI, China). The cytotoxicity effect and the photothermal cellular damage of GNR systems were evaluated on a breast cancer cell line. Results show that polymer coats did not affect the transduction photothermal efficiency. Values around 50% were obtained for the different coated gold nanorods. The cytotoxicity of coated gold nanorods diminished significantly compared with those GNR stabilized with CTAB. The laser irradiation of cells treated with gold nanorods showed a decrease in their viability compared with the cells treated but no irradiated. (C) 2017 Elsevier B.V.All rights reserved.
dc.languageen
dc.publisherElsevier
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceMaterials Science and Engineering C
dc.subjectGold nanorods
dc.subjectPhotothermal efficiency
dc.subjectChitosan
dc.subjectAlginate
dc.subjectCytotoxicity
dc.titlePhotothermal conversion efficiency and cytotoxic effect of gold nanorods stabilized with chitosan, alginate and poly(vinyl alcohol)
dc.typeArtículos de revistas


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