Chile | Artículo de revista
dc.creatorEstrella, Santiago
dc.creatorGarcía Díaz, Diego
dc.creatorCodner Dujovne, Ethel
dc.creatorCamacho Guillen, Patricia
dc.creatorPérez Bravo, Francisco
dc.date.accessioned2017-03-01T19:20:17Z
dc.date.available2017-03-01T19:20:17Z
dc.date.created2017-03-01T19:20:17Z
dc.date.issued2016
dc.identifierMedicina Clínica. Volumen: 147 Número: 6 Páginas: 245-247
dc.identifier0025-7753
dc.identifierhttps://repositorio.uchile.cl/handle/2250/142845
dc.description.abstractBackground and objective: Type 1 diabetes (T1D) is an autoimmune disease of complex aetiology. Several microRNAs (miR) have been linked to the pathogenesis of autoimmune diseases. To analyze the possible association of miR-22 and miR-150 with autoimmunity and clinical severity of T1D. Patients and methods: The study was performed in peripheral blood mononuclear cells of 20 patients with T1D and 20 control subjects. The expression of miR-22 and miR-150 was performed in peripheral blood mononuclear cells using TaqMan probes to different glucose concentrations (baseline, 11 mm, 25 mm). Results: Our results suggest that the expression of miR-22 is increased in T1D patients compared to the controls. This effect was observed in baseline glucose conditions and decreased in 11 and 25 mM of glucose. The expression of miR-150 was lower in T1D patients versus the controls. There was no correlation between the autoimmune profile and the two studied miRNAs. miR-22 (baseline condition) and miR-150 (11 mM condition) or the ketoacidosis component. Conclusion: miR-22 and 150 were not associated with the autoimmune component present in T1D patients. (C) 2016 Elsevier Espana, S.L.U. All rights reserved.
dc.languageen
dc.sourceMedicina Clínica
dc.subjectAutoimmunity
dc.subjectType 1 diabetes
dc.subjectmiR-150
dc.subjectmiR-22
dc.titleExpression of miR-22 and miR-150 in type 1 diabetes mellitus: Possible relationship with autoimmunity and clinical characteristics
dc.typeArtículo de revista


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