Chile
| Artículo de revista
Expression of miR-22 and miR-150 in type 1 diabetes mellitus: Possible relationship with autoimmunity and clinical characteristics
dc.creator | Estrella, Santiago | |
dc.creator | García Díaz, Diego | |
dc.creator | Codner Dujovne, Ethel | |
dc.creator | Camacho Guillen, Patricia | |
dc.creator | Pérez Bravo, Francisco | |
dc.date.accessioned | 2017-03-01T19:20:17Z | |
dc.date.available | 2017-03-01T19:20:17Z | |
dc.date.created | 2017-03-01T19:20:17Z | |
dc.date.issued | 2016 | |
dc.identifier | Medicina Clínica. Volumen: 147 Número: 6 Páginas: 245-247 | |
dc.identifier | 0025-7753 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/142845 | |
dc.description.abstract | Background and objective: Type 1 diabetes (T1D) is an autoimmune disease of complex aetiology. Several microRNAs (miR) have been linked to the pathogenesis of autoimmune diseases. To analyze the possible association of miR-22 and miR-150 with autoimmunity and clinical severity of T1D. Patients and methods: The study was performed in peripheral blood mononuclear cells of 20 patients with T1D and 20 control subjects. The expression of miR-22 and miR-150 was performed in peripheral blood mononuclear cells using TaqMan probes to different glucose concentrations (baseline, 11 mm, 25 mm). Results: Our results suggest that the expression of miR-22 is increased in T1D patients compared to the controls. This effect was observed in baseline glucose conditions and decreased in 11 and 25 mM of glucose. The expression of miR-150 was lower in T1D patients versus the controls. There was no correlation between the autoimmune profile and the two studied miRNAs. miR-22 (baseline condition) and miR-150 (11 mM condition) or the ketoacidosis component. Conclusion: miR-22 and 150 were not associated with the autoimmune component present in T1D patients. (C) 2016 Elsevier Espana, S.L.U. All rights reserved. | |
dc.language | en | |
dc.source | Medicina Clínica | |
dc.subject | Autoimmunity | |
dc.subject | Type 1 diabetes | |
dc.subject | miR-150 | |
dc.subject | miR-22 | |
dc.title | Expression of miR-22 and miR-150 in type 1 diabetes mellitus: Possible relationship with autoimmunity and clinical characteristics | |
dc.type | Artículo de revista |