dc.creator | González Gronow, Mario | |
dc.creator | Cuchacovich Turteltaub, Miguel | |
dc.creator | Francos, Rina | |
dc.creator | Cuchacovich, Stephanie | |
dc.creator | Blanco, Ángel | |
dc.creator | Sandoval, Rodrigo | |
dc.creator | Farías Gómez, Cristian | |
dc.creator | Valenzuela, Javier | |
dc.creator | Ray, Rupa | |
dc.creator | Pizzo, Salvatore | |
dc.date.accessioned | 2015-12-18T13:26:36Z | |
dc.date.available | 2015-12-18T13:26:36Z | |
dc.date.created | 2015-12-18T13:26:36Z | |
dc.date.issued | 2015 | |
dc.identifier | Journal of Neuroimmunology 287 (2015) 1–8 | |
dc.identifier | DOI: 10.1016/j.jneuroim.2015.07.006 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/135841 | |
dc.description.abstract | Autoantibodies from autistic spectrum disorder (ASD) patients react with multiple proteins expressed in the
brain. One such autoantibody targets myelin basic protein (MBP). ASD patients have autoantibodies to MBP of
both the IgG and IgA classes in high titers, but no autoantibodies of the IgMclass. IgA autoantibodies act as serine
proteinases and degradeMBP in vitro. They also induce a decrease in long-termpotentiation in the hippocampi of
rats either perfusedwith or previously inoculated with this IgA. Because this class of autoantibody causes myelin
sheath destruction in multiple sclerosis (MS), we hypothesized a similar pathological role for them in ASD. | |
dc.language | en | |
dc.publisher | Elsevier | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | |
dc.subject | Autism | |
dc.subject | Autoimmunity | |
dc.subject | Myelin basic protein | |
dc.subject | Protease antibodies | |
dc.subject | Synaptic plasticity | |
dc.subject | Rat hippocampi | |
dc.title | Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus | |
dc.type | Artículo de revista | |