dc.creatorMizgier, María Luisa
dc.creatorCasas Atala, Mariana
dc.creatorContreras Ferrat, Ariel Eduardo
dc.creatorLlanos Vidal, Paola
dc.creatorGalgani Fuentes, José
dc.date.accessioned2014-12-17T17:33:45Z
dc.date.accessioned2019-04-26T00:08:09Z
dc.date.available2014-12-17T17:33:45Z
dc.date.available2019-04-26T00:08:09Z
dc.date.created2014-12-17T17:33:45Z
dc.date.issued2014
dc.identifierObesity reviews 15, July 2014, p. 587–597
dc.identifierdoi: 10.1111/obr.12166
dc.identifierhttp://repositorio.uchile.cl/handle/2250/129415
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/2433735
dc.description.abstractPancreatic beta cells sense glucose flux and release as much insulin as required in order to maintain glycaemia within a narrow range. Insulin secretion is regulated by many factors including glucose, incretins, and sympathetic and parasympathetic tones among other physiological factors. To identify the mechanisms linking obesity-related insulin resistance with impaired insulin secretion represents a central challenge. Recently, it has been argued that a crosstalk between skeletal muscle and the pancreas may regulate insulin secretion. Considering that skeletal muscle is the largest organ in non-obese subjects and a major site of insulin- and exercise-stimulated glucose disposal, it appears plausible that muscle might interact with the pancreas and modulate insulin secretion for appropriate peripheral intracellular glucose utilization. There is growing evidence that muscle can secrete so-called myokines that can have auto/para/endocrine actions. Although it is unclear in which direction they act, interleukin-6 seems to be a possible muscle-derived candidate protein mediating such inter-organ communication. We herein review some of the putative skeletal muscle-derived factors mediating this interaction. In addition, the evidence coming from in vitro, animal and human studies that support such inter-organ crosstalk is thoroughly discussed.
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.subjectBeta cell
dc.titlePotential role of skeletal muscle glucose metabolism on the regulation of insulin secretion
dc.typeArtículos de revistas


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