dc.creator | Castro, I. | |
dc.creator | Sepúlveda, D. | |
dc.creator | Cortés, J. | |
dc.creator | Quest, Andrew F. G. | |
dc.creator | Barrera, M. J. | |
dc.creator | Bahamondes, V. | |
dc.creator | Aguilera, S. | |
dc.creator | Urzúa Tobar, Ulises | |
dc.creator | Alliende, C. | |
dc.creator | Molina, C. | |
dc.creator | González, S. | |
dc.creator | Hermoso Ramello, Marcela | |
dc.creator | Leyton Blanca, Cristina | |
dc.creator | González, M. J. | |
dc.date.accessioned | 2014-03-06T19:58:58Z | |
dc.date.accessioned | 2019-04-26T00:07:32Z | |
dc.date.available | 2014-03-06T19:58:58Z | |
dc.date.available | 2019-04-26T00:07:32Z | |
dc.date.created | 2014-03-06T19:58:58Z | |
dc.date.issued | 2013 | |
dc.identifier | Autoimmunity Reviews 12 (2013) 567–574 | |
dc.identifier | doi 10.1016/j.autrev.2012.10.018 | |
dc.identifier | http://repositorio.uchile.cl/handle/2250/129282 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/2433602 | |
dc.description.abstract | Sjögren's syndrome (SS) is a chronic autoimmune disease of undefined etiology. Patients with this syndromesuffer
from severe alterations in both the quality and quantity of saliva and tears, due to impaired function of the
relevant exocrine glands. Prevalent symptoms experienced by SS-patients include a persistent drymouth sensation
(xerostomia) and dry eyes (keratoconjunctivitis sicca). Water content of saliva depends of acetylcholine
levels, glandular innervation,M3R signaling, calciumtunneling andwater release, among other factors.However,
unstimulated salivary flow correlates only poorly with symptoms of mouth dryness, raising the question as to
which other components of saliva may be involved in mouth dryness experienced by SS-patients? Salivary mucins
are glycoproteins characterized by the presence of large oligosaccharide side chains attached to the protein
backbone. These molecules are key saliva components that are required to sequesterwater and thereby moisturize,
aswell as lubricate the oral mucosa. In the labial salivary glands of SS patients,morphological and functional
alterations are detectable that affect the maturation and trafficking of salivary mucins. In this review, we will
focus the discussion on these aspects of reduced salivary flow and decreased quality of salivary mucins, since
they are likely to be responsible for xerostomia in SS-patients. | |
dc.language | en | |
dc.publisher | Elsevier | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.subject | Sjögren's syndrome | |
dc.title | Oral dryness in Sjögren's syndrome patients. Not just a question of water | |
dc.type | Artículos de revistas | |