Artículos de revistas
Inhibition of rat carotid body glomus cells TASK-like channels by acute hypoxia is enhanced by chronic intermittent hypoxia
Fecha
2013Registro en:
Respiratory Physiology & Neurobiology 185 (2013) 600– 607
doi 10.1016/j.resp.2012.11.015
Autor
Ortiz, Fernando C.
Del Rio, Rodrigo
Ebensperger Darrouy, Germán
Reyes Catalán, Víctor
Alcayaga Urbina, Julio
Varas, Rodrigo
Iturriaga, Rodrigo
Institución
Resumen
Chronic intermittent hypoxia (CIH), the main feature of obstructive sleep apnea, enhances carotid body
(CB) chemosensory responses to acute hypoxia. In spite of that, the primary molecular target of CIH
in the CB remains unknown. A key step of the hypoxic response in the CB is the chemoreceptor cell
depolarization elicited by the inhibition of K+ channels. Thus, we tested the hypothesis that CIH potentiates
the hypoxic-induced depolarization of rat CB chemoreceptor cells by enhancing the inhibition of a
background K+ TASK-like channel. Membrane potential, single channel and macroscopic currents were
recorded in the presence of TEA and 4-aminopyridine in CB chemoreceptor cells isolated from adult rats
exposed to CIH. The CIH treatment did not modify the resting membrane properties but the hypoxicevoked
depolarization increased by 2-fold. In addition, the hypoxic inhibition of the TASK-like channel
current was larger and faster in glomus cells from CIH-treated animals. This novel effect of CIH may
contribute to explain the enhancing effect of CIH on CB oxygen chemoreception.