Artículo de revista
Polycystic ovarian morphology in postmenarchal adolescents
Fecha
2011-02Registro en:
Fertility and Sterility, Vol. 95, No. 2, February 2011
doi:10.1016/j.fertnstert.2010.06.015
Autor
Codner Dujovne, Ethel
Villarroel, Claudio
Eyzaguirre, Francisca
López, Patricia
Merino, Paulina
Pérez Bravo, Francisco
Iñíguez Vila, Germán
Cassorla Goluboff, Fernando
Institución
Resumen
Objective: To evaluate the association of polycystic ovary morphology (PCOM) with ovarian function in adolescents
and to determine its time course during two years of follow-up.
Design: Prospective study.
Setting: Academic center.
Patient(s): Twenty healthy adolescents were followed from 2–4 years after menarche.
Intervention(s): We performed annual ultrasonographic and hormonal studies. Ovulation was assessed during
6 consecutive months by measuring salivary progesterone levels.
Main Outcome Measure(s): Persistence of PCOM during the years following menarche; ovulation in girls with
PCOM.
Result(s): PCOM was observed in 40%, 35%, and 33.3% of the ultrasonographic studies performed at 2, 3, and
4 years after menarche, respectively. The concordance between ultrasonographic diagnosis at 2 and 4 years
postmenarche (50%) was nonsignificant (kappa ¼ 0.08). PCOM was not associated with abnormalities in ovulatory
rate, menstrual cycle duration, lipid levels, or homeostatic model assessment of insulin resistance. However, lower
FSH (4.8 1.3 vs. 6.1 1.9 mUI/ml) were observed in girls with PCOM compared with those without PCOM.
Similar T and stimulated 17-hydroxyprogesterone on the leuprolide test were observed in girls with and without
PCOM.
Conclusion(s): PCOM is an inconstant finding in healthy adolescents and does not appear to be associated with
decreased ovulatory rate or metabolic abnormalities in healthy adolescents. This finding suggests that PCOM
may correspond to a physiologic condition during early adolescence.