Artículo de revista
Geographic patterns of genome admixture in Latin American mestizos
Fecha
2008-03Registro en:
PLOS GENETICS, Volume: 4,Issue: 3 Article Number: e1000037, 2008
1553-7390
Autor
Wang, Sijia
Ray, Nicolas
Rojas, Winston
Parra, Maria V.
Bedoya, Gabriel
Gallo, Carla
Poletti, Giovanni
Mazzotti, Guido
Hill, Kim
Hurtado, Ana M.
Camrena, Beatriz
Nicolini, Humberto
Klitz, William
Barrantes, Ramiro
Molina, Julio A.
Freimer, Nelson B.
Cátira Bortolini, María
Salzano, Francisco M.
Petzl-Erler, Maria L.
Tsuneto, Luiza T.
Dipierri, José E.
Alfaro, Emma L.
Bailliet, Graciela
Bianchi, Néstor O.
Llop Romero, Elena
Rothhammer Engel, Francisco
Excoffier, Laurent
Ruiz Linares, Andrés
Institución
Resumen
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of
complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America
has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly
European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 Xchromosome
microsatellites. We found extensive variation in Native American and European ancestry (and generally low
levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often
involved predominantly European men and both Native and African women. An admixture analysis allowing for Native
American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This
observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved
Natives from the area where the Mestizo examined are located. Our findings agree with available information on the
demographic history of Latin America and have a number of implications for the design of association studies in population
from the region.