Chile
| Artículo de revista
Cost-effectiveness of vaccination against cervical cancer: A multi-regional analysis assessing the impact of vaccine characteristics and alternative vaccination scenarios
Fecha
2008-09-15Registro en:
VACCINE, Volume: 26, Pages: F29-F45, Supplement: Suppl. 5, 2008
0264-410X
Autor
Suárez, Eugenio
Smit, Jennifer S.
Bosch, F. Xavier
Nieminen, Pekka
Chen, Chien-Jen
Torvinen, Saku
Demarteau, Nadia
Standaert, Baudouin
Institución
Resumen
Mathematical models provide valuable insights into the public health and economic impact of cervical
cancer vaccination programmes. An in-depth economic analysis should explore the effects of different
vaccine-related factors and vaccination scenarios (independent of screening practices) on health benefits
and costs. In this analysis, a Markov cohort model was used to explore the impact of vaccine characteristics
(e.g. cross-type protection and waning of immunity) and different vaccination scenarios (e.g. age at
vaccination and multiple cohort strategies) on the cost-effectiveness results of cervical cancer vaccination
programmes. The analysis was applied across different regions in the world (Chile, Finland, Ireland,
Poland and Taiwan) to describe the influence of location-specific conditions. The results indicate that in
all the different settings cervical cancer vaccination becomes more cost-effective with broader and sustained
vaccine protection, with vaccination at younger ages, and with the inclusion of several cohorts.
When other factors were varied, the cost-effectiveness of vaccination was most negatively impacted by
increasing the discount rate applied to costs and health effects.