| dc.description.abstract | stimulants has been widely used in the study of diverse
psychiatric disorders. However, the characterization of this
response in normal subjects is still incomplete.
Objective. To compare the response to serotonin stimulation
using dexfenfluramine, a specific serotonergic agent,
in young healthy men and women, controlling the menstrual
cycle.
Methods. A total of 10 women and 9 men, who were
given 30 mg of dexfenfluramine orally, were studied and
their levels of prolactin were measured on an hourly basis
for a five-hour period. Baseline, maximum and delta values
of prolactin were compared for both groups.
Results. According to the age groups studied (mean
age for men: 19.9±2.5 years old; mean age for women: 20±
1.5 years old), the prolactin maximum level and the response
to prolactin (ΔPRL) were significantly higher in women
(p-values: 0.02 and 0.04, respectively).
Conclusion. Young healthy women show a greater response
to stimulation with dexfenfluramine than young
healthy men. Clinical and biological implications of this observation
are discussed in the context of the currently available
research papers. | |
