Artículos de revistas
Effectiveness of systematic spike dithering depends on theprecision of cortical synchronization
Fecha
2008-08Registro en:
BRAIN RESEARCH, Volume: 1225, Special Issue: Sp. Iss. SI, Pages: 39-46, 2008
0006-8993
Autor
Pazienti, Antonio
Maldonado Arbogast, Pedro
Diesmann, Markus
Grün, Sonja
Institución
Resumen
Spike synchronization is a candidate mechanism of cortical information processing. The
widely used method of dithering randomly perturbs the spike times of experimental data to
construct a distribution of coincidence counts enabling an assessment of the significance of
the original data set. The precision of any existing synchrony, however, is limited by the
biophysics of the neural system and detection methods are designed to tolerate an
adjustable temporal spread. Previous works have independently studied the detectability of
jittered spike coincidences and the destruction of precise coincidences by dithering. Here we
derive for the first time how dithering interacts with temporally jittered coincidences. We
demonstrate that the probability of detecting a spike coincidence characteristically decays
with the applied dither interval. This unique relationship enables us to determine the
precision of synchronization in cortical spike data of a freely viewing monkey based on the
analysis for a single setting of tolerated temporal spread.