Artículo de revista
T-kininogen induces endothelial cell proliferation
Fecha
2006-03Registro en:
MECHANISMS OF AGEING AND DEVELOPMENT Volume: 127 Issue: 3 Pages: 282-289 Published: MAR 2006
0047-6374
Autor
Pérez, Viviana
Leiva Salcedo, Elías
Acuña Castillo, Claudio
Aravena, Mauricio
Gómez, Christian
Sabaj Diez, Valeria
Colombo, Alicia
Nishimura, Sumiyo
Pérez Núñez, Claudio
Walter, Robin Ann
Sierra, Felipe
Institución
Resumen
Basal proliferation of endothelial cells increases with age, and this might play a role in the etiology of age-related vascular diseases, as well as angiogenesis. Serum kininogen levels increase during aging in rats and humans, and T-kininogen (T-KG) can affect proliferative homeostasis in several cell models. Both kinins and kininogens have been shown previously to be angiogenic through activation of endothelial cell proliferation, and here we show that exposure of endothelial cells to T-KG results in vigorous cell proliferation, accompanied by ERK/AKT activation. In our experiments, the proliferative response requires B1 and B2 kinin receptors, even though kinins are not released from the precursor. We hypothesize that the age-related increase in T-KG could play a significant role in the age-related dysregulation of vascular physiology and function.