| dc.description.abstract | Aim: To determine risk parameters associated
with high values of high sensitive
C-reactive protein (hsCRP) in subjects with
different glucose fasting levels. Methods:
Anthropometric parameters, arterial pressure,
glycemia, lipid profile, uric acid, and
hsCRP were studied in a population of 513
individuals between 40 and 65 years.
Results: In total, 349 (68.0%) were normoglycemic
(NG); 113 (22.0%) had impaired
fasting glucose (IFG); and 51 (9.9%) were
diabetic subjects. A multivariate linear
regression analysis showed that the natural
logarithm of hsCRP was associated
significantly with glycemia levels
(P50.009), uric acid (P50.001), diastolic
blood pressure (P50.011), smoking habit
(P50.021), BMI (Po0.001), and sex
(Po0.001). One-third of the NG subjects
had high hsCRP levels. A multiple logistic
regression analysis showed that sex and
BMI were variables related to high levels of
hsCRP in subjects with IFG and NG. In NG
subjects, uric acid levels were associated
with risk of presenting high hsCRP levels
and were higher in women than men. In NG
women, ROC curves analysis identified a
uric acid level of 3.9 mg/dl as a cut-off point
to predict a high value of hsCRP. Those
individuals with uric acid values higher than
3.9 mg/dl and normal glycemia had 3.5-fold
more risk of having hsCRP levels over
3.0 mg/l. Conclusions: We sustain that high
levels of hsCRP are associated with disturbance
in carbohydrate metabolism. In
addition, we believe that in low cardiovascular
risk population, such as NG women,
uric acid levels above 3.9 mg/dl might
represent a signal of possible pro-inflammatory
state and cardiovascular risk. | |
