| dc.description.abstract | The incidence and prevalence of diabetes mellitus are both increasing rapidly in societies around the globe.
The majority of patients with diabetes succumb ultimately to heart disease, much of which stems from
atherosclerotic disease and hypertension. However, the diabetic milieu is itself intrinsically noxious to the
heart, and cardiomyopathy can develop independent of elevated blood pressure or coronary artery disease.
This process, termed diabetic cardiomyopathy, is characterized by significant changes in the physiology, structure,
and mechanical function of the heart. Presently, therapy for patients with diabetes focuses largely on
glucose control, and attention to the heart commences with the onset of symptoms. When the latter develops,
standard therapy for heart failure is applied. However, recent studies highlight that specific elements of the
pathogenesis of diabetic heart disease are unique, raising the prospect of diabetes-specific therapeutic intervention.
Here,we reviewrecently unveiled insights into the pathogenesis of diabetic cardiomyopathy and associated
metabolic remodeling with an eye toward identifying novel targets with therapeutic potential. | |
