Rho kinase inhibition activates the homologous angiotensin-converting enzyme-angiotensin-(1-9) axis in experimental hypertension

dc.creatorOcaranza, María Paz
dc.creatorRivera, Paulina
dc.creatorNovoa, Ulises
dc.creatorPinto, Melissa
dc.creatorGonzález, Leticia
dc.creatorChiong Lay, Mario
dc.creatorLavandero González, Sergio
dc.creatorJalil Milad, Jorge
dc.date.accessioned2011-08-08T13:34:12Z
dc.date.available2011-08-08T13:34:12Z
dc.date.created2011-08-08T13:34:12Z
dc.date.issued2011-04
dc.identifierJOURNAL OF HYPERTENSION 29 (4): 706-715
dc.identifier0263-6352
dc.identifierhttp://repositorio.uchile.cl/handle/2250/121576
dc.description.abstractBackground Angiotensin II (Ang II) levels depend on renin, angiotensin-converting enzyme (ACE), and on the homologous angiotensin-converting enzyme (ACE2). Increased ACE and Ang II levels are associated with higher Rho kinase activity. However, the relationship between Rho kinase activation and ACE2 in hypertension is unknown. Objective The role of the Rho kinase signaling pathway in both enzymatic activity and aortic gene expression of ACE2 in deoxycorticosterone acetate (DOCA) hypertensive rats was assessed in the present study.
dc.languageen
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.subjectPULMONARY ARTERIAL-HYPERTENSION
dc.titleRho kinase inhibition activates the homologous angiotensin-converting enzyme-angiotensin-(1-9) axis in experimental hypertension
dc.typeArtículos de revistas


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