Artículo de revista
Synthesis of a Novel Series of 4-Arylpiperazinyl Derivatives Linked to a 2-(Pyridin-3-yl)-1H-benzimidazole as New Delavirdine Analogues
Fecha
2010Registro en:
J. Braz. Chem. Soc., Vol. 21, No. 1, 63-70, 2010.
0103 - 5053
Autor
Pessoa Mahana, David
Núñez, Andrés
Espinosa Bustos, Christian
Mella Raipán, Jaime A.
Pessoa Mahana, Hernán
Institución
Resumen
The synthesis of a series of substituted arylpiperazines linked to a 2-(pyridin-3-yl)-1H-benzo[d]imidazole scaffold through an alkylic linker is reported. The novel 1-(2-(4-arylpiperazin-1-yl)alkyl)-2-(pyridin-3-yl)-1H-benzimidazole derivatives are structurally related to the anti-HIV-1 drug Delavirdine and belong to the bis(heteroaryl)piperazines family (BHAPs), a well known HIV-1 reverse transcriptase inhibitors group.