Extracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth factor-1 on cultured cardiac myocytes

dc.creatorFoncea Avila, Rocío
dc.creatorGálvez, Anita
dc.creatorPérez Montes, Viviana
dc.creatorMorales, María Paz
dc.creatorCalixto, Andrea
dc.creatorMeléndez Vergara, Jaime
dc.creatorGonzález Jara, Fabián Rodrigo
dc.creatorDíaz Araya, Guillermo
dc.creatorSapag Hagar, Mario
dc.creatorSugden, Peter H.
dc.creatorLeRoith, Derek
dc.creatorLavandero González, Sergio
dc.date.accessioned2010-03-26T13:45:46Z
dc.date.available2010-03-26T13:45:46Z
dc.date.created2010-03-26T13:45:46Z
dc.date.issued2000-07-05
dc.identifierBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 273(2): 736-744
dc.identifier0006-291X
dc.identifierhttp://repositorio.uchile.cl/handle/2250/120906
dc.description.abstractThis study aims to elucidate the signaling pathway for insulin-like growth factor-1 (IGF-1) in cultured neonatal rat cardiomyocytes and particularly the role of IGF-1 in cardiac apoptosis, IGF-1 stimulated polyphosphoinositide turnover, translocation of protein kinase C (PKC) isoforms (alpha, epsilon, and delta) from the soluble to the particulate fraction, activation of phospholipid-dependent and Ca2+-, phospholipid-dependent PKC, and activation of the extracellular-regulated kinase (ERK), IGF-1 attenuated sorbitol-induced cardiomyocyte viability and nuclear DNA fragmentation, These antiapoptotic effects of IGF-1 were blocked by PD098059 (an MEK inhibitor) but not by bisindolylmaleimide I (BIM, a specific PKC inhibitor), The ERK pathway may therefore be an important component in the mechanism whereby IGF-1 exerts its antiapoptotic effect on the cardiomyocyte,
dc.languageen
dc.publisherACADEMIC PRESS INC
dc.subjectInsulin-like growth factor-1
dc.titleExtracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth factor-1 on cultured cardiac myocytes
dc.typeArtículos de revistas


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