Artículo de revista
Oxidative stress and inflammation in heart failure: Mechanisms of damage and therapeutic alternatives. Estrés oxidativo e inflamación en insuficiencia cardíaca. Mecanismos de daño y alternativas terapéuticas.
Autor
Miranda, Rodrigo
Castro, Pablo
Verdejo, Hugo
Chiong Lay, Mario
Díaz Araya, Guillermo
Mellado, Rose Marie
Rojas, Diego
Concepción, Roberto
Lavandero González, Sergio
Institución
Resumen
Despite advances in treatment, chronic heart failure still is associated with a pool- prognosis and remains a leading cause of cardiovascular death. Cumulatingi evidence sugigest,; that imbalances in redox state lead to a higber generation Qf reactive ox en species, This phenoinenon, along wilb pro-n flamnzatory cytokine activation.Y9 and extra cellular matrix alterations with reactivefibrosis, play all important role in the pathogenesis andprogression oj'beartftiilure, through the development of endothelial and inyocardial dY-01inction. 7he understanding qf the under yingj phenomena and the metabolic pathways involved will allow further development ql'therapies ainling to chanqe The natural bisloiy of beartft7ilure