Replacement of a proline with silaproline causes a 20-fold increase in the cellular uptake of a pro-rich peptide

dc.creatorPujals, Sílvia
dc.creatorFernández Carneado, Jimena
dc.creatorKogan Bocian, Marcelo
dc.creatorMartínez, Jean
dc.creatorCavelier, Florine
dc.creatorGiralt, Ernest
dc.date.accessioned2009-06-10T16:11:24Z
dc.date.available2009-06-10T16:11:24Z
dc.date.created2009-06-10T16:11:24Z
dc.date.issued2006-07-05
dc.identifierJOURNAL OF THE AMERICAN CHEMICAL SOCIETY Volume: 128 Issue: 26 Pages: 8479-8483 Published: JUL 5 2006
dc.identifier0002-7863
dc.identifierhttps://repositorio.uchile.cl/handle/2250/120664
dc.description.abstractThe results presented here show that elementary design enhancements have led to a 20-fold increase in the cellular uptake properties of a Pro-rich cell-penetrating peptide. These results are relevant not only due to the increasing interest in using CPPs as molecular shuttles for intracellular drug delivery but also because they illustrate the power of combining conformational analysis with rational design to modulate the behavior of biologically active compounds.
dc.languageen
dc.publisherAMER CHEMICAL SOC
dc.subjectN-TERMINAL DOMAIN
dc.titleReplacement of a proline with silaproline causes a 20-fold increase in the cellular uptake of a pro-rich peptide
dc.typeArtículo de revista


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