Artículos de revistas
Nitrofurylsemicarbazone rhenium and ruthenium complexes as anti-trypanosomal agents
Fecha
2006-11Registro en:
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Volume: 41 Issue: 11 Pages: 1231-1239 Published: NOV 2006
0223-5234
Autor
Otero, Lucía
Aguirre, Gabriela
Boiani, Lucía
Denicola, Ana
Rigol Olsen, Carolina
Olea Azar, Claudio
Maya Arango, Juan
Morello Casté, Antonio
González, Mercedes
Gambino, Dinorah
Cerecetto, Hugo
Institución
Resumen
Rhenium and ruthenium complexes of the type [(ReOCl2)-O-V(PPh3)L] and [(RuC2)-C-II(DMSO)(2)L], where L are 5-nitroftitylsemicarbazone derivatives, were prepared in an effort to obtain new anti-trypanosomal agents combining the recognized biological activity of these metals and the trypanocidal activity of the free ligands. Rhenium complexes resulted unstable in aqueous solution not allowing their use as potential drugs. On the other hand, complexation to ruthenium of the bioactive ligands lead to the lack of antiprotozoa activity even though free radical production and redox cycling induction were detected when the compounds were incubated in presence of Trypanosoma cruzi cells. The lack of anti-trypanosomal activity of ruthenium complexes could be explained on the basis of their high protein binding capacity and their high hydrophilicity.