dc.creatorYáñez Soto, Claudia
dc.creatorLápez Alarcón, Camilo Ignacio
dc.creatorCamargo Grandón, Rodrigo
dc.creatorValenzuela, V.
dc.creatorSquella Serrano, Juan
dc.creatorNúñez Vergara, Luis
dc.date.accessioned2008-06-06T16:32:42Z
dc.date.available2008-06-06T16:32:42Z
dc.date.created2008-06-06T16:32:42Z
dc.date.issued2004-05-01
dc.identifierBIOORGANIC & MEDICINAL CHEMISTRY 12(9):2459-2468
dc.identifier0968-0896
dc.identifierhttps://repositorio.uchile.cl/handle/2250/120443
dc.description.abstractA series of eight commercial C-4 substituted 1,4-dihydropyridines and other synthesized related compounds were tested for direct potential scavenger effect towards alkylperoxyl radicals and ABTS radical cation in aqueous Britton-Robinson buffer pH 7.4. A direct quenching radical species was established. The tested 1,4-dihydropyridines were 8.3-fold more reactive towards alkylperoxyl radicals than ABTS cation radical, expressed by their corresponding kinetic rate constants. Furthermore, NPD a photolyte of nifedipine and the C-4 unsubstituted 1,4-DHP were the most reactive derivatives towards alkylperoxyl radicals. The pyridine derivative was confirmed by GOMS technique as the final product of reaction. In consequence, the reduction of alkylperoxyl and ABTS radicals by 1,4-dihydropyridines involved an electron transfer process. Also, the participation of the hydrogen of the 1-position appears as relevant on the reactivity. Results of reactivity were compared with Trolox.
dc.languageen
dc.publisherPERGAMON-ELSEVIER SCIENCE
dc.subject1,4-dihydropyridines
dc.titleStructural effects on the reactivity 1,4-dihydropyridines with alkylperoxyl radicals and ABTS radical cation
dc.typeArtículo de revista


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