Artículos de revistas
Improving Amphetamine Therapeutic Selectivity: N,N-dimethyl-MTA has Dopaminergic Effects and does not Produce Aortic Contraction
Fecha
2014Registro en:
Basic & Clinical Pharmacology & Toxicology, 2014, 114, 395–399
DOI: 10.1111/bcpt.12168
Autor
Sotomayor Zárate, Ramón
Jara, Pablo
Araos, Patricio
Vinet, Raúl
Quiróz, Gabriel
Renard, Georgina M.
Espinosa, Pedro
Hurtado Guzmán, Claudio
Moya, Pablo R.
Iturriaga-Vásquez, Patricio
Gysling, Katia
Reyes Parada, Miguel
Institución
Resumen
Abstract: Amphetamine derivatives have therapeutic potential in diseases such as attention deficit hyperactivity disorder, narcolepsy
and obesity. However, their prolonged use has been associated with cardiovascular toxicity and addiction. In recent years,
we have studied the pharmacological effects of amphetamine derivatives such as methylthioamphetamine (MTA) and N,Ndimethyl-
thioamphetamine, with the aim of improving their therapeutic selectivity. In this work, we show that similarly to MTA,
N,N-dimethyl-thioamphetamine has effects on the dopamine system, producing a significant increase in extracellular levels of
dopamine (as measured by in vivo brain microdialysis) and locomotor activity, which is a behavioural measure of dopaminergic
activation. However, unlike MTA, N,N-dimethyl- thioamphetamine does not produce aortic contraction in vitro. Our results show
that N,N-dimethyl-thioamphetamine is a drug that retains the dopaminergic effects of amphetamine derivatives but exhibits a
lower potential for producing cardiovascular side effects.