Artículo de revista
Microtubule-Associated Protein 1B Function during Normal Development, Regeneration, and Pathological Conditions in the Nervous System
Fecha
2004Registro en:
J Neurobiol 58: 48–59, 2004 DOI 10.1002/neu.10283
1932-846X
Autor
González Billault, Christian
Jiménez Mateos, Eva María
Cáceres, Alfredo
Díaz Nido, Javier
Wandosell, Francisco
Avila, Jesús
Institución
Resumen
Microtubule-associated protein 1B is
the first MAP to be expressed during the development of
the nervous system. Several different approaches have
revealed that MAP1B function is associated with microtubule
and actin microfilament polymerization and dynamics.
In recent years, the generation of molecular
models to inactivate MAP1B function in invertebrates
and mammals has sparked some controversy about the
real role of MAP1B. Despite discrepancies between some
studies, it is clear that MAP1B plays a principal role in
the development of the nervous system. In this article,
we summarize the evidence for MAP1B function in a
wide variety of cellular processes implicated in the
proper construction of the nervous system. We also
discuss the role of MAP1B in pathological processes.