SYNTHESIS OF 2-ARYL-l,3-PROPANEDIAMlNES USING A ONE-POT KNOEVENAGEL-MICHAEL SEQUENCE

Abstract

A simple synthetic route for the preparation of 2-phenyl-I,3-propanediamines, based on a Knoevenagel-Michael double .:ondensation followed by reduction, was developed using nitromethane as reagent and solvent, and sodium bicarbonate as base in ¡he first step, followed by catalytic hydrogenation over Adams catalyst.