Artículos de revistas
A two-step method for the preparation of homochiral cathinones
Fecha
2003-03-12Registro en:
Tetrahedron: Asymmetry Vol. 14, p. 1473–1477, 2003.
0957-4166
Autor
Osorio Olivares, Mauricio
Caroli Rezende, Marcos
Sepúlveda Boza, Silvia
Cassels Niven, Bruce
Baggio, Ricardo
Muñoz Acevedo, Juan Carlos
Institución
Resumen
Abstract—A simple method for the preparation of homochiral ring-substituted 1-aryl-2-aminopropanones 2 (‘cathinones’) is
described, involving initial Friedel–Crafts acylation of aromatics with (S)- or (R)-N-trifluoroacetylalanyl chloride, followed by
acid hydrolysis of the intermediate trifluoroacetamido intermediates 1, for which X-ray diffraction analysis confirmed the
structures.