A quantum-chemical and experimental study of the hallucinogen (k)- 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane (DON)

dc.creatorGómez Jeria, Juan
dc.creatorCassels Niven, Bruce
dc.creatorSaavedra Aguilar, Juan Carlos
dc.date.accessioned2012-05-28T15:18:47Z
dc.date.available2012-05-28T15:18:47Z
dc.date.created2012-05-28T15:18:47Z
dc.date.issued1987-06-05
dc.identifierEur. J. Med. Chem. 22, 433-437, 1987.
dc.identifier0223-5234.
dc.identifierhttps://repositorio.uchile.cl/handle/2250/119424
dc.description.abstractThe electronic structure of 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane (DON) was calculated at the CND0/2 level, and the racemic compound was synthesized and found to be hallucinogenic at doses of 4 mg. DON differs from its similarly active congeners in that a hydrophilic nitro group replaces lipophilic substituents at C-4 of the benzene ring. The implications for the mechanism of serotonin receptor binding of these drugs are discussed.
dc.languageen
dc.publisherElsevier Science
dc.subjectCNDO
dc.titleA quantum-chemical and experimental study of the hallucinogen (k)- 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane (DON)
dc.typeArtículo de revista


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