dc.creator | Aliaga, Alvaro E. | |
dc.creator | Ahumada, Hernán | |
dc.creator | Sepúlveda, K. | |
dc.creator | Gómez Jeria, Juan | |
dc.creator | Garrido, C. | |
dc.creator | Weiss López, Boris | |
dc.creator | Campos Vallette, Marcelo | |
dc.date.accessioned | 2011-10-11T14:32:40Z | |
dc.date.accessioned | 2019-04-25T23:21:45Z | |
dc.date.available | 2011-10-11T14:32:40Z | |
dc.date.available | 2019-04-25T23:21:45Z | |
dc.date.created | 2011-10-11T14:32:40Z | |
dc.date.issued | 2011-03-17 | |
dc.identifier | JOURNAL OF PHYSICAL CHEMISTRY C, Volume: 115, Issue: 10, Pages: 3982-3989, 2011 | |
dc.identifier | 1932-7447 | |
dc.identifier | http://repositorio.uchile.cl/handle/2250/119319 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/2423676 | |
dc.description.abstract | The MRKDV peptide, structurally associated
9 with an immunomodulatory protein, was studied using surface
10 enhanced Raman scattering (SERS), molecular dynamics (MD)
11 simulations, and quantum chemical calculations. The SERS
12 spectrum of the MRKDV peptide adsorbed on the silver surface
13 is dominated by signals coming from the guanidinium moiety of
14 the arginine amino acid (R). Guanidinium is the intrinsic probe
15 that drives the orientation of the peptide onto the silver surface.
16 Molecular mechanics and extended H€uckel calculations of a
17 model of MRKDV interacting with a silver surface support the
18 experimental results. MD calculations representing the evolution of the peptide toward a model membrane were also performed.
19 The guanidinium moiety interacts with the phospholipidic membrane surface. A hydrophobic C-terminal modification favors the
20 peptide membrane affinity. | |
dc.language | en | |
dc.publisher | AMER CHEMICAL SOC | |
dc.subject | ENHANCED RAMAN-SCATTERING | |
dc.title | SERS, Molecular Dynamics and Molecular Orbital Studies of the MRKDV Peptide on Silver and Membrane Surfaces | |
dc.type | Artículos de revistas | |