dc.creator | Bergeron, Sadie A. | |
dc.creator | Milla, Luis A. | |
dc.creator | Villegas, Rosario | |
dc.creator | Shen, Meng-Chieh | |
dc.creator | Burgess, Shawn M. | |
dc.creator | Allende Connelly, Miguel | |
dc.creator | Karlstrom, Rolf O. | |
dc.creator | Palma Alvarado, Verónica | |
dc.date.accessioned | 2011-03-31T12:15:41Z | |
dc.date.available | 2011-03-31T12:15:41Z | |
dc.date.created | 2011-03-31T12:15:41Z | |
dc.date.issued | 2007-12-11 | |
dc.identifier | GENOMICS, Volume: 91, Issue: 2, Pages: 165-177, 2008 | |
dc.identifier | 0888-7543 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/119121 | |
dc.description.abstract | The Hedgehog (Hh) signaling pathway plays critical instructional roles during embryonic development. Misregulation of Hh/Gli signaling is a
major causative factor in human congenital disorders and in a variety of cancers. The zebrafish is a powerful genetic model for the study of Hh
signaling during embryogenesis, as a large number of mutants that affect different components of the Hh/Gli signaling system have been
identified. By performing global profiling of gene expression in different Hh/Gli gain- and loss-of-function scenarios we identified known
(e.g., ptc1 and nkx2.2a) and novel Hh-regulated genes that are differentially expressed in embryos with altered Hh/Gli signaling function. By
uncovering changes in tissue-specific gene expression, we revealed new embryological processes that are influenced by Hh signaling. We thus
provide a comprehensive survey of Hh/Gli-regulated genes during embryogenesis and we identify new Hh-regulated genes that may be targets of
misregulation during tumorigenesis. | |
dc.language | en | |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | |
dc.subject | Hedgehog | |
dc.title | Expression profiling identifies novel Hh/Gli-regulated genes in developing zebrafish embryos | |
dc.type | Artículo de revista | |