Factores asociados a convulsiones como manifestacion aguda de Neurocisticercosis en pacientes de hospitales de San Juan de Pasto e Ipiales durante 2011 – 2015

Abstract

Introduction. The most common clinical presentation of neurocysticercosis are the seizures, and is the leading cause of preventable epilepsy in underdeveloped countries. In this study we evaluated the sociodemographic and clinical factors associated with seizures in an endemic area in Colombia Materials and Methods: Retrospective analytical cross-sectional study in patients with NCC de novo in hospitals of Nariño between 2011 and 2015. Patients with seizures were compared with those who did not present them, using tests such as Chi square, T-student and U of Mann Whitney, according to the nature and distribution of the variables. To identify association, odds ratio (OR) was calculated with its respective confidence interval (95% CI). Results. Fifty-two patients were evaluated, with a mean age of 43.8 years. 56% had single lesions, parenchymal predominance (83%), vesicular stage (87%), and frontal location (52%) and left hemisphere (42%). Seizures were associated with age <36 years (OR4, 95% CI 1.09-4.9, p: 0.03) and lesions in the left hemisphere (OR 13.5, 95% CI 1.9-93 , 2:: 0.008); patients with seizures were associated with a lower probability of intraventricular lesions (OR 0.13, 95% CI 0.025-0.75, p 0.02), posterior fossa lesions (OR 0.13, 95% CI 0.25-0.75 , p = 0.02) or hydrocephaly (OR 0.17, 95% CI 0.03-0.96, p: 0.04) compared to those without seizures. Conclusion: The factors that were associated with a greater probability of seizures were age less than or equal to 36 years and left parenchymal lesions, and seizures were less likely with extraparenchymal lesions.