Efecto del flujo del dializado sobre la ganancia interdialítica en hemodiálisis crónica (Estudio FLUGAIN)

Abstract

Objective: To determine if there is a difference in interdialytic weight gain between patients treated with dialysate flow (Qd) of 400 mL / min vs Qd of 500 mL / min. Design: We conducted an intervention, crossover, randomized, double-blind study in patients with chronic kidney disease on hemodialysis to determine differences in interdialytic weight gain in patients treated with dialysate flow (Qd) of 400 ml / min and 500 ml / min. Patients: We analyzed data from 46 patients on chronic hemodialysis with Qd 400 ml / min and 45 with Qd 500 ml / min. Analysis: : Hypothesis testing for differences in interdialytic weight gain and other variables between groups was performed by paired t test. For the correlation analysis we calculated the Pearson coefficient. Results: There was no significant difference in interdialytic weight gain using QD 400 ml / min vs 500 ml / min (2.37 ± 0.7 vs 2.41 ± 0.6, p = 0.41) nor in Kt / V (1.57 ± 0.25 vs 1.59 ± 0.23, p = 0.45), potassium (4.9 ± 1.1 vs 5.1 ± 1.0, p = 0.45), phosphorus (4.5 ± 1.2 vs 4.4 ± 1.2, p = 0.56) or hemoglobin (11.3 ± 1.8 vs 11.3 ± 1.6, p = 0.96). Conclusions : In patients weighing ≤ 65 kg QD using 400 ml / min is not associated with lower interdialytic weight gain. We found no difference in dialysis efficiency which suggests that lowering Qd is a safe intervention at short term.