Relationship between handgrip strength and muscle mass in female survivors of breast cancer: A mediation analysis

dc.contributorRamírez-Vélez, Robinson
dc.contributorCorrea Bautista, Jorge Enrique
dc.creatorBenavides Rodriguez, Cindy
dc.date.accessioned2017-08-11T20:58:11Z
dc.date.available2017-08-11T20:58:11Z
dc.date.created2017-08-11T20:58:11Z
dc.date.issued2017
dc.identifierhttp://repository.urosario.edu.co/handle/10336/13647
dc.identifierhttps://doi.org/10.48713/10336_13647
dc.description.abstractThis study explored the mediating factors of sarcopenia in a group of women survivors of breast cancer in Bogotá, Colombia. This was a descriptive crosssectional study with 98 women survivors of breast cancer, who were registered with the SIMMON (Integrated Synergies to Improve Oncological Management in Colombia) Foundation. Body weight, height, and waist circumference (WC) were measured, and body mass index (BMI) was calculated. Body composition (percentage of fat and muscle mass) was evaluated via four-pole bioelectrical impedance analysis. Sarcopenia was defined as low muscle mass plus low grip strength or low gait speed (EWGSOP criteria). A "causal" mediation analysis with the Baron & Kenny procedure (PROCESS® macro) was used to explore variables related to sarcopenia. Analyses were performed with the IBM SPSS 21 statistical package (SPSS, Inc., Chicago, Illinois, USA). The significance level of the results obtained in the hypothesis contrast was p < 0.05. The mean age of the sample was 65.5±5.9 years, with a BMI of 27.8±4.7 kg/m2. The prevalence of sarcopenia was 22.4%. Linear regression models suggest a partial mediation of anthropometric parameters (body mass, body mass index and waist circumference) in the association between handgrip strength and muscle mass. In conclusion, one in every five women survivors of breast cancer had sarcopenia. The findings seem to emphasize the importance of obesity prevention in women survivors of breast cancer, suggesting that high handgrip strength may not relate closely to greater muscle mass and therefore would not exclude the risk of sarcopenia.
dc.languagespa
dc.publisherUniversidad del Rosario
dc.publisherMaestría en Actividad Física y Salud
dc.publisherFacultad de medicina
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAbierto (Texto completo)
dc.rightsEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.
dc.sourceFerlay J, Shin H, Bray F, Forman D, Mathers C, Parkin D. GLOBOCAN 2014, Cancer incidence and mortality worldwide: IARC Cancer Base No 11. Lyon, France: International Agency for Research on Cancer; 2014.
dc.sourceOspina ML, Huertas JA, Montaño JI, Rivillas JC. Observatorio Nacional de Cáncer Colombia. Facultad Nacional de Salud Pública. 2015;33(2):262-76.
dc.sourceOspina ML, Huertas JA, Montaño JI, Rivillas JC. Observatorio Nacional de Cáncer Colombia. Facultad Nacional de Salud Pública. 2015;33(2):262-76.
dc.sourceFrenzel AP, Pastore CA, González MC. The influence of body composition on quality of life of patients with breast cancer. Nutr Hosp. 2013;28(5):1475-82.
dc.sourceBayar MA, Antoun S, Lanoy E. Statistical approaches for evaluating body composition markers in clinical cancer research. Expert Rev Anticancer Ther. 2017; 17(4):311-318.
dc.sourceCarneiro IP, Mazurak VC, Prado CM. Clinical Implications of Sarcopenic Obesity in Cancer. Curr Oncol Rep. 2016;18(10):62.
dc.sourcePrado CM, Cushen SJ, Orsso CE, Ryan AM. Sarcopenia and cachexia in the era of obesity: clinical and nutritional impact. Proc Nutr Soc. 2016; 75(2):188-98.
dc.sourcePoggiogalle E, Migliaccio S, Lenzi A, Donini LM. Treatment of body composition changes in obese and overweight older adults: insight into the phenotype of sarcopenic obesity. Endocrine. 2014; 47(3):699-716.
dc.sourceSantilli V, Bernetti A, Mangone M, Paoloni M. Clinical definition of sarcopenia. Clin Cases Miner Bone Metab. 2014; 11(3):177-80.
dc.sourceAnandavadivelan P, Brismar TB, Nilsson M, Johar AM, Martin L. Sarcopenic obesity: A probable risk factor for dose limiting toxicity during neo-adjuvant chemotherapy in oesophageal cancer patients. Clin Nutr. 2016;35(3):724-30.
dc.sourceMartin L, Birdsell L, Macdonald N, Reiman T, Clandinin MT, McCargar LJ, et al. Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index. J Clin Oncol 2013; 31:1539-47.
dc.sourceDemark-Wahnefried W, Kenyon AJ, Eberle P, Skye A, Kraus WE. Preventing sarcopenic obesity among breast cancer patients who receive adjuvant chemotherapy: results of a feasibility study. Clin Exerc Physiol. 2002;4(1):44-9.
dc.sourceVillasenor A, Ballard-Barbash R, Baumgartner K, Baumgartner R, Bernstein L, McTiernan A, et al. Prevalence and prognostic effect of sarcopenia in breast cancer survivors: the HEAL Study. J Cancer Surviv. 2012;6(4):398-406
dc.sourceLieffers JR, Bathe OF, Fassbender K, Winget M, Baracos VE. Sarcopenia is associated with postoperative infection and delayed recovery from colorectal cancer resection surgery. Br J Cancer 2012;107:931-36.
dc.sourceCruz-Jentoft AJ, Landi F, Schneider SM, Zúñiga C, Arai H, Boirie Y, Chen LK, Fielding RA, Martin FC, Michel JP, et al. Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS). Age Ageing. 2014; 43(6):748-59.
dc.sourceGómez JF, Curcio C-L, Alvarado B, Zunzunegui MV, Guralnik J. Validez y confiabilidad de la batería corta de desempeño físico (SPPB): un estudio piloto sobre la movilidad en los Andes colombianos. Colomb Med. 2013;44(3):165-72.
dc.sourceKim J-H, Cho JJ, Park YS. Relationship between sarcopenic obesity and cardiovascular disease risk as estimated by the Framingham risk score. J Korean Med Sci. 2015;30(3):264-71.
dc.sourcePreacher KJ, Hayes AF. Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behav Res Methods. 2008; 40:879–891. 19 Menard S. Applied Logistic Regression Analysissage University. Thousand Oaks, CA: Sage; 1995.
dc.sourceMyers RH. Classical and modern regression with applications (Duxbury Classic). Pacific Grove: Duxbury Press; 2000.
dc.sourceStenholm S, Harris TB, Rantanen T, Visser M, Kritchevsky SB, Ferrucci L. Sarcopenic obesity: definition, cause and consequences. Curr Opin Clin Nutr Metab Care. 2008;11(6):693-700.
dc.sourceBaumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR, Garry PJ, Lindeman RD. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 1998; 147: 755-63.
dc.sourceMelton LJ, 3rd, Khosla S, Crowson CS, O’Connor MK, O’Fallon WM, Riggs BL. Epidemiology of sarcopenia. J Am Geriatr Soc 2000; 48: 625-30.
dc.sourceYamada M, Nishiguchi S, Fukutani N, Tanigawa T, Yukutake T, Kamaya H, Aoyama T, Arai H. Prevalence of Sarcopenia in Community-Dwelling Japanese Older Adults. J Am Med Dir Assoc. 2013;14(12):911-15.
dc.sourceBianchi L, Ferrucci L, Cherubini A, Maggio M, Bandinelli S, Savino E, Brombo G, Zuliani G, Guralnik JM, Landi F, Volpato S. The Predictive Value of the EWGSOP Definition of Sarcopenia: Results From the InCHIANTI Study. J Gerontol A Biol Sci Med Sci. 2016;71(2):259- 64.
dc.sourceArango-Lopera VE, Arroyo P, Gutiérrez-Robledo LM, Pérez-Zepeda MU, Cesari M. Mortality as an adverse outcome of sarcopenia. J Nutr Health Aging. 2013; 17(3): 259 – 262.
dc.sourceCastro EA, Lima LM, Cerqueira MS, Gobbi S, Doimo LA. Sarcopenia and cardiovascular risk in physically active adult and elderly women. Motriz: Revista de Educação Física, 2014; 20(1):92-99.
dc.sourceChien MY, Huang TY, Wu YT. Prevalence of Sarcopenia Estimated Using a Bioelectrical Impedance Analysis Prediction Equation in Community-Dwelling Elderly People in Taiwan. J Am Geriatr Soc. 2008;56(9):1710-15.
dc.sourceGonzález-González DR, López-Salazar AM, González-Correa CH. Resultados preliminares de un estudio sobre prevalencia de sarcopenia en ancianos. RACGG 2014; 15: 1-13.
dc.sourceDasarathy S, Merli M. Sarcopenia from mechanism to diagnosis and treatment in liver disease. J Hepatol. 2016; 65(6):1232-44.
dc.sourceArgilés, JM, López-Soriano, FJ. The ubiquitin- dependent proteolytic pathway in skeletal muscle: its role in pathological states. Trends Pharmacol Sci 1996;17:223-6.
dc.sourceEgerman, MA, Glass DJ. Signaling pathways controlling skeletal muscle mass. Crit. Rev. Biochem. Mol Biol 2014;49:59-68.
dc.sourceGoodpaster BH, Kelley DE, Thaete FL, He J, Ross R. Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content. J Appl Physiol (1985). 2000;89(1):104-10
dc.sourceIdoate F, Cadore EL, Casas-Herrero A, Zambom-Ferraresi F, Marcellán T, Ruiz de Gordoa A, Rodriguez-Mañas L, Bastarrika G, Marques MC, Martínez-Velilla N, Vicente-Campos D, Izquierdo M. Adipose tissue compartments, muscle mass, muscle fat infiltration, and coronary calcium in institutionalized frail nonagenarians. Eur Radiol. 2015; 25(7):2163-75.
dc.sourceIdoate F, Cadore EL, Casas-Herrero A, Zambom-Ferraresi F, Martínez-Velilla N, RodriguezMañas L, Azcárate PM, Bottaro M, Ramírez-Vélez R, Izquierdo M.Noncoronary Vascular Calcification, Bone Mineral Density, and Muscle Mass in Institutionalized Frail Nonagenarians. Rejuvenation Res. 2017 Mar 24. doi: 10.1089/rej.2016.1868.
dc.sourceLexell J., Taylor C. C., Sjöström M. What is the cause of the ageing atrophy?J. Neurol. Sci. 1988;84:275-94
dc.sourceTan BH, Birdsell LA, Martin L, Baracos VE, Fearon KC. Sarcopenia in an overweight or obese patient is an adverse prognostic factor in pancreatic cancer. Clinical Cancer Research 2009;15:6973-9.
dc.sourceSakuma K, Aoi W, Yamaguchi A. Molecular mechanism of sarcopenia and cachexia: recent research advances. Pflugers Arch. 2017;469:573-91.
dc.sourceCesari M, Kritchevsky SB, Baumgartner RN, Atkinson HH, Penninx BW, Lenchik L, Palla SL, Ambrosius WT, Tracy RP, Pahor M. Sarcopenia, obesity, and inflammation—results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study. Am J Clin Nutr 2005; 82: 428-34.
dc.sourceGlass, DJ. Signaling pathways perturbing muscle mass. Curr Opin Clin Nutr Metab Care 2010;13:225-9.
dc.sourceYeh SS, Schuster MW. Geriatric cachexia: the role of cytokines. Am J Clin Nutr 1999; 70: 183- 97.
dc.sourceFantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 2005; 115: 911-9
dc.sourceDas UN. Is obesity an inflammatory condition? Nutrition 2001; 17: 953-66.
dc.sourceKalinkovich A, Livshits G. Sarcopenic obesity or obese sarcopenia: A cross talk between ageassociated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis. Ageing Res Rev. 2017; 35:200-21.
dc.sourceSakuma K, Aoi W, Yamaguchi A. Molecular mechanism of sarcopenia and cachexia: recent research advances. Pflugers Arch. 2017;469(5-6):573-91.
dc.sourcePrado CM, Baracos VE, McCargar LJ, Reiman T, Mourtzakis M, Tonkin K, Mackey JR, Koski S, Pituskin E, Sawyer MB. Sarcopenia as a determinant of chemotherapy toxicity and time to tumor progression in metastatic breast cancer patients receiving capecitabine treatment. Clin Cancer Res. 2009;15(8):2920-6.
dc.sourceRier HN, Jager A, Sleijfer S, van Rosmalen J, Kock MC, Levin MD. Low muscle attenuation is a prognostic factor for survival in metastatic breast cancer patients treated with first line palliative chemotherapy. Breast. 2017;31:9-15.
dc.sourceBiolo G, Cederholm T, Muscaritoli M. Muscle contractile and metabolic dysfunction is a common feature of sarcopenia of aging and chronic diseases: from sarcopenic obesity to cachexia. Clin Nutr. 2014;33(5):737-48.
dc.sourceCleasby ME, Jamieson PM, Atherton PJ. Insulin resistance and sarcopenia: mechanistic links between common co-morbidities. J Endocrinol. 2016;229(2):R67-81. 50 Kob R, Bollheimer LC, Bertsch T, Fellner C, Djukic M, Sieber CC, Fischer BE. Sarcopenic obesity: molecular clues to a better understanding of its pathogenesis? Biogerontology. 2015; 16(1):15-29.
dc.sourceBiolo G, Cederholm T, Muscaritoli M. Muscle contractile and metabolic dysfunction is a common feature of sarcopenia of aging and chronic diseases: from sarcopenic obesity to cachexia. Clin Nutr. 2014; 33(5):737-48.
dc.sourceLee DC, Shook RP, Drenowatz C, Blair SN. Physical activity and sarcopenic obesity: definition, assessment, prevalence and mechanism. Future Sci OA. 2016;2(3):FSO127.
dc.sourceFox KR, Stathi A, McKenna J, Davis MG. Physical activity and mental well-being in older people participating in the Better Ageing Project. Eur J Appl Physiol. 2007;100(5):591-602
dc.sourceMeneses-Echávez JF, Correa-Bautista JE, González-Jiménez E, Schmidt Río-Valle J, Elkins MR, Lobelo F, Ramírez-Vélez R. The Effect of Exercise Training on Mediators of Inflammation in Breast Cancer Survivors: A Systematic Review with Meta-analysis. Cancer Epidemiol Biomarkers Prev. 2016;25(7):1009-17.
dc.sourceHojan K, Milecki P, Molinska-Glura M, Roszak A, Leszczynski P. Effect of physical activity on bone strength and body composition in breast cancer premenopausal women during endocrine therapy. Eur J Phys Rehabil Med. 2013;49:331-39.
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.subjectPrevalence
dc.subjectBody composition
dc.subjectSarcopenia
dc.subjectBreast cancer
dc.subjectPhysical performance
dc.subjectAdults
dc.titleRelationship between handgrip strength and muscle mass in female survivors of breast cancer: A mediation analysis
dc.typemasterThesis


Este ítem pertenece a la siguiente institución