masterThesis
Cáncer colorrectal hereditario no asociado a polipósis - Síndrome de Lynch. Articulo de revisión
Fecha
2017Autor
Martínez Hincapié, Cristina Isabel
Pérez Montaguth, Luis Francisco
Baquero Zamarra, David Ricardo
Barco, Andrés
Institución
Resumen
Hereditary nonpolyposis colorectal cancer (HNPCRC) also known as Lynch syndrome (LS) is recognized as an autosomal dominant hereditary syndrome of incomplete penetrance, characterized by mutations in DNA repair genes (Mismatch Repair Genes). It is the most frequent of all the hereditary syndromes, and increases the likelihood of developing colorectal cancer, representing 2-3% of all colorectal cancers (CRC). This syndrome predisposes to metachronous (CRC) and other extracolonic cancers as endometrium, small bowel, ureter and renal pelvis among others. Therefore, it is necessary to recognize this syndrome and identify individuals with HNPCRC to prevent, diagnose and provide, if possible, early treatment in an effort to decrease its morbidity and mortality.