Factores asociados con la duración del circuito extracorpóreo en terapias continúas de reemplazo renal en la Fundación Cardioinfantil

Abstract

Introduction: continuous renal replacement therapies (CRRTs) are an important measure to use in patients with acute kidney injury attending to the intensive care unit. Early loss of the extracorporeal circuit by coagulation is an situation that affects this group of patients. Materials and Methods: A case and control study was conducted. Duration of study was three months. Patients underwent to CRRTs at Fundación Cardioinfantil were included. Cases were defined by patients failing to complete 72 hours of therapy because of circuit coagulation, conversely for controls (longer than 72 hours). Both groups were analyzed according to different demographic, clinical and circuit variables. Primary analysis used only the first filter and a secondary analysis included all filters. Results: 24 patients for the primary analysis and 101 filters for secondary analysis were collected. 37.5% of the filters lasted > 72 hours and 62.5% suffer early loss of circuit. The APACHE II score (OR 0.76, p 0.003) and right femoral insertion site (OR: 0.14, p 0.007) were found protective for early dysfunction. Discussion: although the total sample was not reached, the right femoral access was found protective, being a new finding, however further confirmation is required. The APACHE II, also protective, may correspond to a bias. Other studies to clarify these findings and determine the presence of other variables involved are needed.