Genotipificación de HLA-B en pacientes colombianos afectados por el síndrome Stevens-Johnson y la Necrólisis Epidérmica Tóxica

dc.contributorRestrepo, Carlos M.
dc.creatorLeón Ruiz, Maria Juliana
dc.date.accessioned2014-09-18T14:39:04Z
dc.date.available2014-09-18T14:39:04Z
dc.date.created2014-09-18T14:39:04Z
dc.date.issued2014
dc.identifierhttp://repository.urosario.edu.co/handle/10336/8910
dc.identifierhttps://doi.org/10.48713/10336_8910
dc.description.abstractStevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions (SCARs) characterized by exanthema, erosion of the skin and mucous membranes, blistering, skin detachment secondary to keratinocyte death, and ocular involvement. There are uncommon in the population but with high morbidity and mortality. In Asia has been associated HLA-B*15:02 allele as a genetic marker for SJS. In Colombia there are no data on the incidence of these SCARs, neither the relationship with potential and specific drugs or genomic studies of susceptibility genes.
dc.languagespa
dc.publisherUniversidad del Rosario
dc.publisherMaestría en Ciencias con Énfasis en Genética Humana
dc.publisherFacultad de medicina
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAbierto (Texto completo)
dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombia
dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombia
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dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.subjectSíndrome Stevens Johnson
dc.subjectNecrólisis Epidérmica Tóxica
dc.subjectHLA-B
dc.titleGenotipificación de HLA-B en pacientes colombianos afectados por el síndrome Stevens-Johnson y la Necrólisis Epidérmica Tóxica
dc.typemasterThesis


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