Tiempo promedio del efecto máximo de la insulina análoga en la glucemia postprandial y factores relacionados

Abstract

Introduction: The average time of maximum effect of rapid insulin in postprandial glycemia using regular insulin has been considered for years of 120 minutes. In patients with Diabetes Mellitus type 1 and 2 using analogue insulin, the time and associated factors to be applied in self-monitoring have not been reported yet. The objective of this study was to calculate the time and factors related to the maximal effect of insulin in postprandial glycemia. Methods: A retrospective longitudinal study was developed from a review of medical history of 80 patients. Descriptive and bivariate analyses were performed with demographic and clinical variables of the population. Results: The average time of peak insulin in patients with DM1 was 78.4 (SD ± 16,512) and DM2 75.01 (SD ± 12.02) minutes. 75% of the population with DM1 and 54.2% in DM2 were female, the average age of DM1 was 42.38 years and DM2 68 years, as to the categorization of BMI 50% of the population in DM1 and 37.5% in DM2 were within the range of obesity. A relationship with respect to the type of food "breakfast-dinner" vs. the average time of maximal effect of insulin calculated for both groups (p = 0.010) was found. Conclusion: The average time of maximal effect of insulin calculated was lower than reported in the clinical literature of 120 minutes. The type of main meal showed a relationship with the average time of maximum effect in both groups.