Incidencia y factores asociados a infección en el primer año postrasplante cardiaco
Sanabria Gutiérrez, Pedro Ernesto
Objective: To determine the incidence of infections in the first year after heart Transplant and the factors associated with infections in this period. Materials and methods: analytical case-control study nested in a cohort with heart transplant patients in the Fundación Cardioinfantil – Instituto de Cardiología from 2005 to 2015. Univariate analysis, bivariate analysis between the study variables and the outcome for the selection of variables for the logistic regression model. Results: A median of 54 years in the cohort, with a higher proportion of men (75.8%) and common occurrence of dilated cardiomyopathy as transplant indication was presented. The incidence of infections in the first year after transplantation was 45% (30/66). Increased risk of infection was found in the first three months, 36.3% (95% CI 23-55), showing higher frequency of lung infections and skin. Among the most important organisms isolated in the first three months, they gram negative bacilli and Aspergillus spp were found. At first year of transplant dilated cardiomyopathy OR 4.7 (CI 95% 1.3 - 17) and chronic kidney disease OR 6.7 (CI 95% 1.4 - 32) were associated with infection. Conclusions: The frequency of infection in heart transplant patients in the IC Cardioinfantil Foundation is similar to that observed in the literature. The occurrence of infections in the first year after transplantation, is associated with the presence of dilated cardiomyopathy and chronic kidney disease.