masterThesis
Infección por virus sincitial respiratorio y su relación con valores de IGG en niños críticos
Fecha
2016Autor
Bonilla González, Carolina
Institución
Resumen
Background: Respiratory Syncytial Virus (RSV) infection represents a high morbidity and mortality, and in some cases management in pediatric intensive care units (PICU). The immune response directly influences the severity and prognosis of patients with respiratory infection. Methodology: A retrospective study of a cohort of patients with severe RSV respiratory infection and no history of immunodeficiency was conducted in the PICU of San Rafael University Hospital Clinic. Global descriptive analysis was performed and according to the categorization of IgG tests analysis. Results: Of 188 patients admitted to the PICU, 13% had RSV infection (24), with an average age of 7. 3 (SD = 3. 6) months; 79. 83% were male. Twelve point five percent had a low value of IgG, 58. 33% had a lower limit value and 29. 17% within the normal range for their age. In patients with low IgG was higher septic shock unresponsive to liquids (100 vs 92 vs 86%), median days of mechanical ventilation (8 vs 6 vs 5, respectively) and mortality (67 vs 7. 1 vs 0%). Conclusion: Our series found that patients with low levels or lower limit values of IgG had more systemic involvement, longer duration of mechanical ventilation and increased mortality. Prospective studies are needed that low levels of IgG relationships with severity and prognosis for these patients with severe RSV infection.