dc.creatorAlbarracín, Sonia
dc.creatorLareo, Leonardo R.
dc.date.accessioned2014-07-09T15:56:03Z
dc.date.available2014-07-09T15:56:03Z
dc.date.created2014-07-09T15:56:03Z
dc.date.issued2010
dc.identifier2145-4507
dc.identifier1692-7273
dc.identifierhttp://repository.urosario.edu.co/handle/10336/7477
dc.description.abstractThe ionotropic glutamate receptor activated by N-methyl-D-aspartate (iGluR-NMDA) is a multiheteromeric complex constituted from by three to five subunits belonging to by three different kinds of subunits known as NR1, NR2AD y NR3A y B. It is well established the participation of iGluR-NMDA complexes in a broad range of physiological, pathological, and as intermediary in pharmacological processes of neural systems. In the CNS, iGluR-NMDA participates in learning, memory, plasticity, neural differentiation, neural migration, and apoptosis, among others. In addition, from the pharmacological point of view the iGluR-NMDA is playing a role in excitotoxicity, drugs-addiction and other dependences. How the same complex can participate in a significant broad group of neural activities is a valid question after a literature review. A carefully analysis shows that iGluR-NMDA interacts, at some level, with a big number of intracellular proteins belonging to signaling proteins family, support proteins, modulator proteins, cytoskeleton, and enzymes, resulting in interactions with more than a 160 proteins, at different interaction levels and acting with intracellular proteins. In this work we report a proposal for a model of differential signaling cascade pathways generated by the iGluR-NMDA gating. The model shows at least the possibility of three different signaling pathways.
dc.languagespa
dc.publisherUniversidad del Rosario
dc.publisherEscuela de Medicina y Ciencias de la Salud
dc.relationhttp://revistas.urosario.edu.co/index.php/revsalud/article/view/521
dc.rightshttp://creativecommons.org/licenses/by-nc/4.0
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAbierto (Texto completo)
dc.sourceRevista Ciencias de la Salud; Vol. 5, núm. 2 (2007)
dc.sourceRevista Ciencias de la Salud; Vol. 5, No. 2 (2007)
dc.sourceRevista Ciencias de la Salud; v. 5, n. 2 (2007)
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.subjectReceptor
dc.subjectHomeostasis
dc.subjectRegulación
dc.subjectCascadas
dc.subjectNeurona
dc.titleModelo integrador para las rutas de señalización diferencial del receptor ionotrópico de glutamato activado por el N-metil-D-aspartato
dc.typearticle


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