Respuesta inflamatoria sistémica en el donante como predictor de infección en el primer mes del trasplante renal

Abstract

Introduction: The main objective of donor selection is to reduce the possibility of transmission of infectious or neoplastic diseases to the receptor, it is estimated that approximately 50% of potential donors are contraindicated, in most of the cases these contraindications is associated with the presence of systemic inflammatory response (SIRS) and / or the presence of infection. The high demand for organs has forced to reconsider many of the contraindications that until recently were absolute and today are considered relative. One of the difficulties in donor selection is the possibility to differentiate the presences of SIRS cause by Brain Death (ME) or SIRS as a result of the infection in the donor.

Method: Retrospective cohort study; which seeks to evaluate the systemic inflammatory response (SIRS) as predictor of infection in kidney transplant patients in the first month after transplantation.

Results: The chi-square test for hypothesis testing provided a bilateral significance (P = 0.071). Rejecting the alternative hypothesis and accepting the null hypothesis: "There is no association between the presences of SIRS in the donor and the incidence of infection in the first month after renal transplantation. The estimated risk of infection readmission for the first month after renal transplantation is 0.881 times for donors with SIRS (IC 95% 0757-1025).

Conclusion: Although the results of our research are not statistically significant given the size of the sample; we consider that the medical history and routine examinations in the donor still have an important role in decision making at the time of the classification of the donor, especially the measuring of risk for infectious transmission to the receiver.