Factores pronósticos en la agudeza visual final de pacientes con oclusión venosa retiniana tratados con terapia antiangiogénica

Abstract

Objective: To determine the different clinical and imaging factors as prognostic factors for final visual acuity at 3,6 and 12 months in patients with retinal vein occlusion treated with antiangiogenic therapy. Methods: Longitudinal study of a cohort of patients with retinal vein occlusion treated with intravitreal antiangiogenic therapy taken retrospectively between 2010 and 2012. Subsequently we conducted a retrospective cohort analysis study to establish the association and predicting changes in visual acuity. Results: We found a statistically significant difference between the baseline, 3, 6 and 12 months post treatment. (p <0.001, Friedman test). In the explanatory model of changes in visual acuity at 3, 6 and 12 months with the baseline, significant association was found between the presence of IS / OS at 3 months with changes in visual acuity at 6 months (r2 = .232, p <0.001) and 12 months (r2= .506, p< 0.001), the latter was also found associated with male gender (r2 = .277 p <0.001). Taking the values of visual acuity at 3,6 and 12 months and as a covariate initial visual acuity; significant association was found in the three moments, at three months (r2 = 0.697, p <0.001), 6 months (r2 = 745, p <0.001) and 12 months (r2 = 786, p <0.001), Significant association was found to present branch vein occlusion central occlusion compared with changes in visual acuity at 6 months (r2 = .662, p = 0.04) Conclusion: Conclusion: The presence of IS / OS at 3 months and initial visual acuity have a high capacity to predict visual acuity at 6 and 12 months, gender is related to final visual acuity and branch occlusion is related to visual acuity at 6 months.