Parámetros cuantitativos de la resonancia magnética cerebral en esclerosis múltiple y su correlación con la discapacidad
TEME 0009 2011
Vargas Bazurto, Maria
Although MR imaging is essential for diagnosis and evaluation of multiple sclerosis, a clinical-MR imaging correlation have not been well established. Objective: Quantitative analysis of normalized brain volume and T1-weighted hypointense lesions can be useful to elucidate a better correlation in this clinical-radiological paradox. Material and methods: Fundación Cardioinfantil patients with multiple sclerosis with an extended disability scale score were entered in this retrospective study. FSL was used to quantify brain parenchyma volume, gray matter volume, white matter volume and hypointense lesions on T1WI on magnetic resonance images. MR results were correlated with the extended disability scale scores. Spearman´s rank correlation coefficient and Student s and Hotelling s t tests were performed. Results: 58 patients were included. There was a moderate correlation between extended disability scale and disease duration of 0.384, 0.386 and 0.389 with normalized brain volume, normalize gray matter volume and low signal intensity lesions respectively for the whole sample. There was not significant correlation between normalized white matter volume and disability. Conclusions: There is a clinical-magnetic resonance correlation in multiple sclerosis. MR parameters are associated to clinical disability and disease duration, hence, magnetic resonance imaging can be used to monitor disease progression and as a outcome in treatment trials.