dc.creatorCardenas Roldan, Jorge
dc.creatorRojas-Villarraga, Adriana
dc.creatorAnaya, Juan-Manuel
dc.date.accessioned2014-08-12T15:21:38Z
dc.date.available2014-08-12T15:21:38Z
dc.date.created2014-08-12T15:21:38Z
dc.date.issued2013
dc.identifierISSN:1741-7015
dc.identifierhttp://repository.urosario.edu.co/handle/10336/8804
dc.description.abstractBackground: A primary characteristic of complex genetic diseases is that affected individuals tend to cluster in families (that is, familial aggregation). Aggregation of the same autoimmune condition, also referred to as familial autoimmune disease, has been extensively evaluated. However, aggregation of diverse autoimmune diseases, also known as familial autoimmunity, has been overlooked. Therefore, a systematic review and meta-analysis were performed aimed at gathering evidence about this topic. Methods: Familial autoimmunity was investigated in five major autoimmune diseases, namely, rheumatoid arthritis, systemic lupus erythematosus, autoimmune thyroid disease, multiple sclerosis and type 1 diabetes mellitus. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were followed. Articles were searched in Pubmed and Embase databases. Results: Out of a total of 61 articles, 44 were selected for final analysis. Familial autoimmunity was found in all the autoimmune diseases investigated. Aggregation of autoimmune thyroid disease, followed by systemic lupus erythematosus and rheumatoid arthritis, was the most encountered. Conclusions: Familial autoimmunity is a frequently seen condition. Further study of familial autoimmunity will help to decipher the common mechanisms of autoimmunity.
dc.languageeng
dc.publisherUniversidad del Rosario
dc.relationBMC MEDICINE ISSN: 1741-7015 V. 11 N. 73 Mar, 2013
dc.relationhttp://www.biomedcentral.com/content/pdf/1741-7015-11-73.pdf
dc.relationNo. 73
dc.relationBMC MEDICINE
dc.relationVol. 11
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAbierto (Texto completo)
dc.rightsEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.titleHow do autoimmune diseases cluster in families? A systematic review and meta-analysis
dc.typearticle


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