masterThesis
Dexmedetomidina vs Remifentanil en fast track (transito rápido) durante cirugía cardiaca
Fecha
2009Registro en:
TEME 0028 2009
Autor
Franco Gruntorad, Germán Andrés
Institución
Resumen
Fast Track Cardiac Anesthesia techniques has become popular during the last years, being remifentanil as the primary drug for the achievement of a quick extubation, due to its ultrashort half live, it is necessary to optimize patient analgesia with opioids after surgery, increasing respiratory complications. On the other hand dexmedetomidine reduces opioid consumption and respiratory depression being a good alternative for fast track cardiac Anesthesia. After IRB 40 patients were randomized in 2 groups group 1 remifentanil based anesthesia, group 2 dexmedetomidine based anesthesia, the primary endpoint, was the extubation time, also opioid consumption during the first 24h postop, incidence of nausea and vomiting, and use of inotropic drugs were measure. There was no statistically significant difference between the extubation times of both groups: group 1 (9.6min) vs group 2 (11.7min), but the incidence of nausea and vomiting during the first 24 hours, and the morphine consumption were both less in the dexmedetomidine group than the remifentanil group. To our knowledge this is the first clinical trial were dexmedetomidine is used as a primary agent for fast track cardiac anesthesia with encouraging results that should be confirmed in further studies.